Acrylonitrile Produces Transient Cochlear Function Loss and Potentiates Permanent Noise-Induced Hearing Loss
نویسندگان
چکیده
منابع مشابه
Acrylonitrile produces transient cochlear function loss and potentiates permanent noise-induced hearing loss.
There is growing evidence that agents that produce oxidative stress in the cochlea have significant ototoxic potential by themselves and can potentiate noise-induced hearing loss as well. Acrylonitrile (ACN) metabolism entails conjugation with glutathione, resulting in rapid and pronounced depletion of this important antioxidant in many organs including brain, liver, and kidney. ACN metabolism ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2003
ISSN: 1096-0929
DOI: 10.1093/toxsci/kfg169